Epilepsy was 33 years and was highest among middle

Epilepsy is a chronic and serious
neurological disorder with multifarious
un-certainties and stigmatization which have significant negative role in the
QOL of those PLWE, in which lack of medication adherence plays a major role.
The main objective of the study was to determine the impact of pharmacist
assisted patient counseling for improving medication adherence and QOL in
epileptic patients.

In our study, we saw that incidence of
epilepsy can occur at any age, in this study the mean age of population was 33
years and was highest among middle adulthood. This is comparable with study
done by Emanuela BB et al30 who reported that the median of age of
the study population was 33 years without significant differences in patient
age based on gender.

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Incidence noticed that the most affected
gender were males (60%) and females (40%). This result is correspondent with
Hiwot G et al58, the study shows that 59.4% were males and 40.6%
females. The results of our study indicated that mostly males were showing non
adherence to AEDs than female.

Marital status and education are major
concerns in epilepsy patients. In our study 71% of study population were
married. More than half of the population were literate and only 2% were
illiterate. However many other studies reveal that high percentage of patients
were illiterate.

Among all the type of epilepsy Generalized
tonic clonic seizure (GTCS) was found to be pre-dominant in our study.81% of
the patients had generalized type of epilepsy. Study conducted by Shakirullah
et al18, shows that GTCS type of epilepsy is common among other type
of epilepsy.

During our study we observed that control
of seizure attack is the main objective in management of epilepsy. There was a
variation in the number of seizure attacks in enrolled study patients. The
majority of patients reported 1-3 attacks per year.  Based on our data seizure can be triggered by
various factors which includes stress 33% , missed medication 27%, lack of
sleep 7%, alcohol consumption 7%, special time 7% , poor follow-up 7% and
unknown factors 12% , a  study conducted
by E. Balamurugan et al.10 supports our data.

In our study we observed the pattern of
AED treatment given to PLWE.Monotherapy which is the gold standard of managing
epilepsy, 53% of patients were administered antiepileptic monotherapy. However
patients who do not respond to monotherapy were prescribed poly therapy (two or
more drugs ) with the aim of controlling seizure. In this study 47% of PLWE
were given poly-therapy. Nuruluni A et al2 got similar result. In
monotherapy most widely used drugs were Phenytoin 63%, Levetiracetam 15% ,
Divalproex sodium 6%, Phenobarbital 5%, Carbamazepine 5% ,Valproic acid 5% and
Lamotrigine 1% .In poly-therapy most commonly prescribed combination was
phenytoin with phenobarbital. This is supported by study conducted by Sanjeev
V.T et al42.  Major side
effects related to therapy reported by the subjects include weakness, headache
gastric irritation, joint pain, hypersensitivity reaction, rashes, weight gain,
memory deficit and nystagmus. Out of this weakness was the major side effect
experienced by the patients. Martin H.H et al60 observed drowsiness
as the major side effect related to AED therapy.

In our study we used validated structured
questionnaire and QOLIE-31 for measuring medication adherence and QOL in
epilepsy patients respectively. During our research, we were able to see that
medication adherence is the major factor influencing the QOL of epileptic
patients, high medication adherence results in seizure control which in turn
positively affect patient QOL. In our study a significant correlation
(p